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Eur J Mass Spectrom (Chichester). 2017 Aug;23(4):192-196. doi: 10.1177/1469066717719810.

Is myelin basic protein a potential biomarker of brain cancer?

Author information

1
1 Institute of Biomedical Chemistry (IBMC), Moscow, Russia.
2
2 Blokhin Russian Cancer Research Center, Moscow, Russia.
3
3 Skolkovo Institute of Science and Technology (Skoltech), Skolkovo, Russia.

Abstract

Myelin basic protein is a potential biomarker for the central nervous system diseases in which the myelin sheath is destroyed. Using pseudo-selected reaction monitoring and the method of standard additions, we have measured the myelin basic protein level in the cerebrospinal fluid of patients with neurotrauma (n = 6), chronic neurodegenerative diseases (n = 2) and brain cancer (n = 5). Myelin basic protein was detected only in four out of five cerebrospinal fluid samples of patients with brain cancer. The cerebrospinal fluid myelin basic protein level ranged from 3.7 to 8.8 ng ml-1. We suggest that monitoring of myelin basic protein in cerebrospinal fluid can serve as a diagnostic test for the brain cancer.

KEYWORDS:

Proteomics; brain cancer; cerebral spinal fluid; myelin basic protein; pseudo-selected reaction monitoring

PMID:
29028399
DOI:
10.1177/1469066717719810
[Indexed for MEDLINE]

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