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Nutrients. 2017 Oct 13;9(10). pii: E1120. doi: 10.3390/nu9101120.

Vitamin D and Age-Related Macular Degeneration.

Author information

1
Clínica Universidad de Navarra, University of Navarra, 31009 Pamplona, Spain. aglayana@unav.es.
2
Dipartimento di Scienze Otorinolaringoiatriche e Oftalmologiche, Universita' Cattolica del Sacro Cuore, Lgo F. Vito 1, 00168 Roma, Italy. aminnella59@gmail.com.
3
Department of Clinical Pharmacology, University of Vienna, 1090 Vienna, Austria. gerhard.garhoefer@meduniwien.ac.at.
4
School of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK. tariq.aslam@manchester.ac.uk.
5
Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, M13 9WL Manchester, and Heriot Watt University, Edinburgh EH14 4AS, UK. tariq.aslam@manchester.ac.uk.
6
Department of Ophthalmology, University of Bonn, D-53107 Bonn, Germany. Frank.Holz@ukb.uni-bonn.de.
7
Department of Ophthalmology, University Hospitals Leuven, 3000 Leuven, Belgium. anita.leys@uzleuven.be.
8
Faculty of Medicine, Institute for Biomedical Imaging and Life Sciences (IBILI), University of Coimbra, 3000-548 Coimbra, Portugal. rufino.silva@oftalmologia.co.pt.
9
Centro Hospitalar e Universitário de Coimbra (CHUC), Department of Ophthalmology, 3000-548 Coimbra, Portugal. rufino.silva@oftalmologia.co.pt.
10
Centro Hospitalar e Universitário de Coimbra (CHUC), Faculty of Medicine, Institute for Biomedical Imaging and Life Sciences (IBILI-FMUC), University of Coimbra, 3000-548 Coimbra, Portugal. rufino.silva@oftalmologia.co.pt.
11
Centro Hospitalar e Universitário de Coimbra (CHUC), Association for Innovation and Biomedical Research on Light and Image (AIBILI), 3000-548 Coimbra, Portugal. rufino.silva@oftalmologia.co.pt.
12
University of Bordeaux, INSERM, Bordeaux Population Health Research Center, Team LEHA, UMR 1219, F-33000 Bordeaux, France. Cecile.Delcourt@isped.u-bordeaux2.fr.
13
Hôpital Intercommunal de Créteil, University Paris Est, 94010 Créteil, France. eric.souied@chicreteil.fr.
14
Department of Ophthalmology, Tufts University School of Medicine, Boston, MA 02111, USA. jseddon@tuftsmedicalcenter.org.
15
Ophthalmic Epidemiology and Genetics Service, Tufts Medical Center, Boston, MA 02111, USA. jseddon@tuftsmedicalcenter.org.

Abstract

In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.

KEYWORDS:

age-related macular degeneration; angiogenesis; inflammation; vitamin D

PMID:
29027953
PMCID:
PMC5691736
DOI:
10.3390/nu9101120
[Indexed for MEDLINE]
Free PMC Article

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