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Pediatr Gastroenterol Hepatol Nutr. 2017 Sep;20(3):139-146. doi: 10.5223/pghn.2017.20.3.139. Epub 2017 Sep 26.

Probiotics in Children: What Is the Evidence?

Hojsak I1,2,3.

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Children's Hospital Zagreb, Zagreb, Croatia.
University of Zagreb, School of Medicine, Zagreb, Croatia.
University Josip Juraj Strossmayer, School of Medicine Osijek, Osijek, Croatia.


The number of papers discussing probiotics increases tremendously that limits the possibility for primary care physicians and clinicians to stay updated. Therefore, the aim of this paper will be to summarize available evidence of probiotic use in well-defined clinical indications of importance for pediatricians. Based on currently available evidence certain probiotic strains (Lactobacillus rhamnosus GG [LGG] and Saccharomyces boulardii) have proven effect in the treatment of acute gastroenteritis and prevention of antibiotic associated diarrhea. Furthermore, LGG was proven to be effective in prevention of nosocomial diarrhea and respiratory tract infection in day care centers. In conclusion, not all probiotic strains have same efficacy for all clinical indications, therefore, only strains with proven efficacy and safety should be recommended.


Bifidobacterium; Diarrhea; Infection; Lactobacillus; Saccharomyces

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