Format

Send to

Choose Destination
Chemosphere. 2018 Jan;190:417-430. doi: 10.1016/j.chemosphere.2017.09.129. Epub 2017 Sep 28.

A case study to identify priority cytostatic contaminants in hospital effluents.

Author information

1
Research Group in Environmental Toxicology and Risk Assessment (TAyER), Rey Juan Carlos University, Avda Tulipán. s/n, 28933 Móstoles, Madrid, Spain. Electronic address: adrianolalla@gmail.com.
2
Water and Soil Quality Research Group, Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain; International Iberian Nanotechnology Laboratory (INL), Avda, Mestre José Veiga s/n, 4715 Braga, Portugal.
3
Water and Soil Quality Research Group, Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.
4
Water and Soil Quality Research Group, Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain; Catalan Institute for Water Research (ICRA), H2O Building, Scientific and Technological Park of the University of Girona, Emili Grahit 101, 17003 Girona, Spain.
5
Research Group in Environmental Toxicology and Risk Assessment (TAyER), Rey Juan Carlos University, Avda Tulipán. s/n, 28933 Móstoles, Madrid, Spain; Department of Medicine and Surgery, Psychology, Preventive Medicine and Public Health, Immunology and Medical Microbiology, Faculty of Health Sciences, Rey Juan Carlos University, Avda. Atenas, s/n, 28922 Alcorcón, Madrid, Spain. Electronic address: Yolanda.valcarcel@urjc.es.

Abstract

This study analyses the presence of 17 cytostatic agents from seven different groups, based on their different mechanisms of action, in the effluent from a medium-sized hospital located in eastern Spain. Analysis of the compounds found in the effluents studied involved solidphase extraction (SPE) coupled on-line to a high performance liquid chromatograph tandem mass spectrometer (HPLC-MS/MS). The environmental risk of the compounds studied was then assessed by calculating the hazard quotient (HQ), combining the measured environmental concentrations (MECs) with dose-response data based on the predicted no effect concentrations (PNECs). In addition, the environmental hazard associated was evaluated in accordance with their intrinsic characteristics by calculating the PBT (Persistence Bioaccumulation Toxicity) index. The results of this study showed the presence of seven of the 17 compounds analysed in a range of between 25 and 4761 ng/L. The highest concentrations corresponded to ifosfamide (58-4761 ng/L), methotrexate (394-4756 ng/L) and cyclophosphamide (46-3000 ng/L). Assessment of the environmental hazard showed that the three hormonal agents (tamoxifen and its metabolites endoxifen and hydroxytamoxifen) exhibited a maximum PBT value of 9 due to their inherent harm to the environment resulting from their characteristics of persistence, bioaccumulation and toxicity. A combined evaluation of the risk and environmental hazard showed that three of the 17 compounds studied, namely, ifosfamide, imatinib and irinotecan, all of which exhibited HQ values higher than 10 and PBT indices of 6, indicative of a particularly high potential to harm the environment, deserve special attention.

KEYWORDS:

Cytostatic agents; Environmental hazard; Environmental risk; Hospital effluents; Priority contaminants

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center