Format

Send to

Choose Destination
Neuron. 2017 Oct 11;96(2):414-427.e8. doi: 10.1016/j.neuron.2017.09.024.

The Anterior Insular Cortex→Central Amygdala Glutamatergic Pathway Is Critical to Relapse after Contingency Management.

Author information

1
Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, Baltimore, MD, USA. Electronic address: venniro.marco@nih.gov.
2
Department of Physiology and Pharmacology "Vittorio Erspamer" Sapienza University of Rome, Rome, Italy.
3
Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, Baltimore, MD, USA.
4
Electron Microscopy Core, Intramural Research Program, NIDA, NIH, Baltimore, MD, USA.
5
University of Camerino School of Pharmacy, Pharmacology Unit, Camerino, Italy.
6
Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, the Netherlands.
7
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
8
Department of Diagnostic & Public Health, University of Verona, Verona, Italy.
9
Integrative Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, Baltimore USA.
10
Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, Baltimore, MD, USA. Electronic address: yshaham@intra.nida.nih.gov.

Abstract

Despite decades of research on neurobiological mechanisms of psychostimulant addiction, the only effective treatment for many addicts is contingency management, a behavioral treatment that uses alternative non-drug reward to maintain abstinence. However, when contingency management is discontinued, most addicts relapse to drug use. The brain mechanisms underlying relapse after cessation of contingency management are largely unknown, and, until recently, an animal model of this human condition did not exist. Here we used a novel rat model, in which the availability of a mutually exclusive palatable food maintains prolonged voluntary abstinence from intravenous methamphetamine self-administration, to demonstrate that the activation of monosynaptic glutamatergic projections from anterior insular cortex to central amygdala is critical to relapse after the cessation of contingency management. We identified the anterior insular cortex-to-central amygdala projection as a new addiction- and motivation-related projection and a potential target for relapse prevention.

KEYWORDS:

CNO; DREADD; amygdala; choice; contingency management; dopamine receptor; insular cortex; methamphetamine; relapse; retrograde tracing

PMID:
29024664
PMCID:
PMC5687288
DOI:
10.1016/j.neuron.2017.09.024
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center