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Pediatr Obes. 2018 Jun;13(6):365-373. doi: 10.1111/ijpo.12250. Epub 2017 Oct 12.

Body composition measurement in young children using quantitative magnetic resonance: a comparison with air displacement plethysmography.

Author information

1
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
2
Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
3
Department of Diagnostic and Interventional Imaging, KK Women's and Children's Hospital, Singapore.
4
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore.
5
Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore.
6
Duke-National University of Singapore Graduate Medical School, Singapore.
7
Department of Neonatology, KK Women's and Children's Hospital, Singapore.
8
Liggins Institute, University of Auckland, New Zealand.
9
MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, UK.
10
Departments of Pediatrics and of Epidemiology, Biostatistics and Occupational Health, McGill University Faculty of Medicine, Canada.
11
Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, A*STAR, Singapore.
12
Department of Pediatric Endocrinology, KK Women's and Children's Hospital, Singapore.
13
Khoo Teck Puat- National University Children's Medical Institute, National University Health System, Singapore.

Abstract

BACKGROUND:

Quantitative magnetic resonance (QMR) has been increasingly used to measure human body composition, but its use and validation in children is limited.

OBJECTIVE:

We compared body composition measurement by QMR and air displacement plethysmography (ADP) in preschool children from Singapore's multi-ethnic Asian population (n = 152; mean ± SD age: 5.0 ± 0.1 years).

METHODS:

Agreements between QMR-based and ADP-based fat mass and fat mass index (FMI) were assessed using intraclass correlation coefficient (ICC), reduced major axis regression and Bland-Altman plot analyses. Analyses were stratified for the child's sex.

RESULTS:

Substantial agreement was observed between QMR-based and ADP-based fat mass (ICC: 0.85) and FMI (ICC: 0.82). Reduced major axis regression analysis suggested that QMR measurements were generally lower than ADP measurements. Bland-Altman analysis similarly revealed that QMR-based fat mass were (mean difference [95% limits of agreement]) -0.5 (-2.1 to +1.1) kg lower than ADP-based fat mass and QMR-based FMI were -0.4 (-1.8 to +0.9) kg/m2 lower than ADP-based FMI. Stratification by offspring sex revealed better agreement of QMR and ADP measurements in girls than in boys.

CONCLUSIONS:

QMR-based fat mass and FMI showed substantial agreement with, but was generally lower than, ADP-based measures in young Asian children.

KEYWORDS:

Air displacement plethysmography; QMR; body composition; quantitative magnetic resonance

PMID:
29024557
PMCID:
PMC5805128
DOI:
10.1111/ijpo.12250
[Indexed for MEDLINE]
Free PMC Article

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