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Chembiochem. 2017 Dec 14;18(24):2404-2407. doi: 10.1002/cbic.201700545. Epub 2017 Nov 9.

Regulating DNA Self-assembly by DNA-Surface Interactions.

Author information

1
Purdue University, Department of Chemistry, West Lafayette, IN, 47906, USA.
2
Hefei University of Technology, School of Chemistry and Chemical Engineering, Hefei, Anhui, 230009, China.
3
Nanchang University, College of Chemistry, Nanchang, Jiangxi, 330031, China.
4
Capital Medical University, Beijing Tiantan Hospital, Department of General Surgery, Beijing, 100050, China.

Abstract

DNA self-assembly provides a powerful approach for preparation of nanostructures. It is often studied in bulk solution and involves only DNA-DNA interactions. When confined to surfaces, DNA-surface interactions become an additional, important factor to DNA self-assembly. However, the way in which DNA-surface interactions influence DNA self-assembly is not well studied. In this study, we showed that weak DNA-DNA interactions could be stabilized by DNA-surface interactions to allow large DNA nanostructures to form. In addition, the assembly can be conducted isothermally at room temperature in as little as 5 seconds.

KEYWORDS:

DNA-surface interactions; nanostructures; nanotechnology; self-assembly

PMID:
29024338
DOI:
10.1002/cbic.201700545
[Indexed for MEDLINE]

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