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J Small Anim Pract. 2018 Mar;59(3):167-173. doi: 10.1111/jsap.12771. Epub 2017 Oct 11.

Serum cardiac troponin I concentrations in dogs with generalised seizures.

Author information

1
Cheshire Cardiology, Knutsford, Cheshire WA16 8NE, UK.
2
Carmichael Torrance Diagnostic Services, Garforth, West Yorkshire LS25 1NB, UK.
3
ChesterGates Veterinary Specialists, Neurology Department, Chester CH1 6LT, UK.
4
PJC Clinical Epidemiology, Neston, Cheshire CH64 0SW, UK.
5
The Royal Veterinary College, Cardiology Department, Hatfield, Hertfordshire AL9 7TA, UK.

Abstract

OBJECTIVES:

To determine if serum cardiac troponin I concentrations - measured with both a first-generation assay and a high-sensitivity assay - were greater in dogs with generalised seizures than in controls and to identify clinical variables associated with cardiac troponin I concentration.

MATERIALS AND METHODS:

Prospective study of 30 dogs with recent generalised seizures and 30 healthy controls. Serum cardiac troponin I concentration was measured using two commercially available assays, and the correlation of clinical factors with concentration was examined.

RESULTS:

Serum concentrations of cardiac troponin I were higher in dogs that had recent seizures compared to controls when measured by both assays. The predictors most clearly associated with cardiac troponin I concentration were number of seizures and age. Both predictors were positively associated with increasing concentrations of troponin I.

CLINICAL SIGNIFICANCE:

Serum cardiac troponin I concentration was significantly elevated in dogs that had recent generalised seizures when compared to controls, and concentrations were higher in dogs that experienced more seizures. This association may indicate that generalised seizures are associated with damage to the myocardium.

PMID:
29023739
DOI:
10.1111/jsap.12771

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