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Pak J Biol Sci. 2016;19(4):185-190. doi: 10.3923/pjbs.2016.185.190.

Measurement of Interleukin-6 in Cerebrospinal Fluid for the Diagnosis of Bacterial Meningitis.

Author information

1
Centre de Recherche Medicale et Sanitaire (CERMES), 634 Boulevard de la Nation YN034, BP 10887, Niamey, Niger.
2
Faculte des Sciences et Techniques, Universite Abdou Moumouni, BP 10 662, Niamey, Niger.

Abstract

OBJECTIVE:

It is assessed whether the measurement of interleukin-6 in the cerebrospinal fluid can serve as a biomarker for the diagnosis of bacterial meningitis.

METHODOLOGY:

Cerebrospinal fluid was obtained from 152 patients aged 0-15 years suspected of having meningitis. These patients were classified into the following groups: Bacterial meningitis (n = 85), aseptic meningitis (n = 35) and non-meningitis/control (n = 32) based on leukocyte count and bacterial identification by culture and molecular biology. Interleukin-6 concentrations in cerebrospinal fluid were measured by enzyme-linked immunosorbent assay.

RESULTS:

This study found a significant difference of the mean cerebrospinal fluid interleukin-6 level (p≤0.01) between patients with bacterial meningitis (3,538.69±2,560.78 pg mL -1) and patients with aseptic meningitis (332.51±470.69 pg mL -1) or those of the control group (205.83±79.39 pg mL -1). There was also a significant difference of the mean cerebrospinal fluid interleukin-6 level between patients with aseptic meningitis and those of the control group. Interleukin-6 had the highest area under the ROC curve: 0.94 (95% confidence interval: 0.901-0.979) compared to that of cerebrospinal fluid glucose and total protein. At a cut-off value of 1,065.96 pg mL -1, interleukin-6 had a sensitivity of 76.2% and specificity of 100%.

CONCLUSION:

Interleukin-6 is a potential biomarker for the differential diagnosis of meningitis.

KEYWORDS:

Measurement; bacterial meningitis; cerebrospinal fluid; diagnosis; interleukin-6

PMID:
29022995
DOI:
10.3923/pjbs.2016.185.190
[Indexed for MEDLINE]

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