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J Gen Virol. 2017 Nov;98(11):2635-2644. doi: 10.1099/jgv.0.000944. Epub 2017 Oct 12.

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication.

Author information

1
1​The Pirbright Institute, Ash Rd Pirbright, Surrey GU24 0NF, UK.
2
2​Food and Agriculture Organization of the United Nation, FAO, 00153 Rome, Italy.
3
3​MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK.
4
4​College of Medical and Dental Sciences, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Abstract

Peste des petits ruminants virus (PPRV) is a significant pathogen of small ruminants and is prevalent in much of Africa, the Near and Middle East and Asia. Despite the availability of an efficacious and cheap live-attenuated vaccine, the virus has continued to spread, with its range stretching from Morocco in the west to China and Mongolia in the east. Some of the world's poorest communities rely on small ruminant farming for subsistence and the continued endemicity of PPRV is a constant threat to their livelihoods. Moreover, PPRV's effects on the world's population are felt broadly across many economic, agricultural and social situations. This far-reaching impact has prompted the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) to develop a global strategy for the eradication of this virus and its disease. PPRV is a morbillivirus and, given the experience of these organizations in eradicating the related rinderpest virus, the eradication of PPRV should be feasible. However, there are many critical areas where basic and applied virological research concerning PPRV is lacking. The purpose of this review is to highlight areas where new research could be performed in order to guide and facilitate the eradication programme. These areas include studies on disease transmission and epidemiology, the existence of wildlife reservoirs and the development of next-generation vaccines and diagnostics. With the support of the international virology community, the successful eradication of PPRV can be achieved.

KEYWORDS:

Morbillivirus; PPRV eradication; Veterinary virology; animal health; peste des petits ruminants; virus eradication

PMID:
29022862
PMCID:
PMC5845661
DOI:
10.1099/jgv.0.000944
[Indexed for MEDLINE]
Free PMC Article

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