Format

Send to

Choose Destination
Nat Prod Res. 2018 Dec;32(24):2887-2892. doi: 10.1080/14786419.2017.1385023. Epub 2017 Oct 12.

α-Glucosidase inhibitory and cytotoxic botryorhodines from mangrove endophytic fungus Trichoderma sp. 307.

Author information

1
a School of Marine Sciences , Sun Yat-Sen University , Guangzhou , China.
2
b Zhongshan School of Medicine , Sun Yat-Sen University , Guangzhou , China.
3
c School of Chemistry , Sun Yat-Sen University , Guangzhou , China.
4
d South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center , Sun Yat-Sen University , Guangzhou , China.

Abstract

One new depsidone, botryorhodine H (1), together with three known analogues, botryorhodines C, D and G (2-4), were obtained from the mangrove endophytic fungus Trichoderma sp. 307 by co-culturing with Acinetobacter johnsonii B2. Structures were determined by 1D and 2D NMR analyses and high-resolution mass spectrum. Compounds 1-3 showed α-glucosidase inhibitory activity with IC50 ranging from 8.1 to 11.2 μM, and compound 1 exhibited potent cytotoxicity against rat prolactinoma MMQ and rat pituitary adenoma GH3 cell lines (IC50 = 3.09 and 3.64 μM).

KEYWORDS:

sp; Botryorhodine H; cytotoxicity; endophytic fungus; α-glucosidase inhibitory activity

PMID:
29022767
DOI:
10.1080/14786419.2017.1385023
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center