Format

Send to

Choose Destination
Pediatr Radiol. 2018 Mar;48(3):437-442. doi: 10.1007/s00247-017-3997-4. Epub 2017 Oct 12.

Enhancement of multiple cranial and spinal nerves in vanishing white matter: expanding the differential diagnosis.

Author information

1
Department of Radiology and Medical Imaging, University of Virginia Medical Center, 1215 Lee St., Charlottesville, VA, 22908, USA. tje6d@virginia.edu.
2
Pediatric Neurology Division, Department of Neurology, University of Virginia Medical Center, 1221 Lee St., Charlottesville, VA, 22908, USA.
3
Department of Radiology and Medical Imaging, University of Virginia Medical Center, 1215 Lee St., Charlottesville, VA, 22908, USA.

Abstract

Abnormal cranial or spinal nerve contrast enhancement on MRI in cases of suspected pediatric leukodystrophy is recognized as an important clue to the diagnosis of either metachromatic leukodystrophy or globoid cell leukodystrophy (Krabbe disease). We report a case of genetically confirmed childhood vanishing white matter with enhancement of multiple cranial and spinal nerves in addition to the more typical intracranial findings. This case expands the limited differential diagnosis of cranial nerve or spinal nerve enhancement in cases of suspected leukodystrophy and may aid in more efficient work-up and earlier diagnosis of vanishing white matter.

KEYWORDS:

Brain; Child; Cranial nerves; Leukodystrophy; Magnetic resonance imaging; Spinal nerves; Vanishing white matter

PMID:
29022088
DOI:
10.1007/s00247-017-3997-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center