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Nat Rev Microbiol. 2017 Oct 12;15(11):697-703. doi: 10.1038/nrmicro.2017.103.

Diagnosing antimicrobial resistance.

Author information

1
Department of Pathology &Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St. Louis, Missouri 63110, USA.
2
Novartis Institutes for Biomedical Research, Inc., Infectious Diseases Area, 5300 Chiron Way, Emeryville, California 94608, USA.
3
Medical and Molecular Microbiology Department of Medicine, INSERM European Laboratory (French National Institute for Health and Medical Research, Paris), Natural Reference Center for Emerging Antibiotic Resistance, University of Fribourg, Chemin du Musée 18, 1700 Fribourg, Switzerland.
4
Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
5
Antibiotic Resistance Coordination and Strategy Unit, National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, Georgia 30329-4027, USA.

Abstract

Antimicrobial resistance constitutes a global burden and is one of the major threats to public health. Although the emergence of resistant microorganisms is a natural phenomenon, the overuse or inappropriate use of antimicrobials has had a great effect on resistance evolution. Rapid diagnostic tests that identify drug-resistant bacteria, determine antimicrobial susceptibility and distinguish viral from bacterial infections can guide effective treatment strategies. Moreover, rapid diagnostic tests could facilitate epidemiological surveillance, as emerging resistant infectious agents and transmission can be monitored. In this Viewpoint article, several experts in the field discuss the drawbacks of current diagnostic methods that are used to identify antimicrobial resistance, novel diagnostic strategies and how such rapid tests can inform drug development and the surveillance of resistance evolution.

PMID:
29021600
DOI:
10.1038/nrmicro.2017.103
[Indexed for MEDLINE]

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