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Physiology (Bethesda). 2017 Nov;32(6):453-463. doi: 10.1152/physiol.00016.2017.

Lactic Acid: No Longer an Inert and End-Product of Glycolysis.

Author information

1
Department of Nephrology, Xijing Hospital, the Fourth Military Medical University, Xian, China.
2
Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; and.
3
Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota qian.qi@mayo.edu.

Abstract

For decades, lactic acid has been considered a dead-end product of glycolysis. Research in the last 20+ years has shown otherwise. Through its transporters (MCTs) and receptor (GPR81), lactic acid plays a key role in multiple cellular processes, including energy regulation, immune tolerance, memory formation, wound healing, ischemic tissue injury, and cancer growth and metastasis. We summarize key findings of lactic acid signaling, functions, and many remaining questions.

PMID:
29021365
DOI:
10.1152/physiol.00016.2017
[Indexed for MEDLINE]
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