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FEBS Lett. 1988 Oct 10;238(2):307-14.

Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA.

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  • 1Department of Biochemistry C, Panum Institute, University of Copenhagen, Denmark.


The complete primary structure (967 amino acids) of an intestinal human aminopeptidase N (EC was deduced from the sequence of a cDNA clone. Aminopeptidase N is anchored to the microvillar membrane via an uncleaved signal for membrane insertion. A domain constituting amino acid 250-555 positioned within the catalytic domain shows very clear homology to E. coli aminopeptidase N and contains Zn2+ ligands. Therefore these residues are part of the active site. However, no homology of the anchor/junctional peptide domain is found suggesting that the juxta- and intra-membraneous parts of the molecule have been added/preserved during development. It is speculated that this part carries the apical address.

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