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Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec;390(12):1177-1188. doi: 10.1007/s00210-017-1429-5. Epub 2017 Oct 10.

Meeting report of the 8th International Conference on cGMP "cGMP: generators, effectors, and therapeutic implications" at Bamberg, Germany, from June 23 to 25, 2017.

Author information

1
Institute of Physiology, University of Würzburg, Röntgenring 9, 97070, Würzburg, Germany.
2
Drug Discovery, Bayer AG, Aprather Weg 18a, 42096, Wuppertal, Germany. peter.sandner@bayer.com.
3
Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. peter.sandner@bayer.com.
4
Institute of Pharmacology, College of Pharmacy, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt, Germany.

Abstract

Although the Nobel Prize for the discovery of nitric oxide (NO) dates back almost 20 years now, the knowledge about cGMP signaling is still constantly increasing. It looks even so that our understanding of the role of the soluble guanylyl cyclase (sGC) and particulate guanylyl cyclase (pGC) in health and disease is in many aspects at the beginning and far from being understood. This holds even true for the therapeutic impact of innovative drugs acting on both the NO/sGC and the pGC pathways. Since cGMP, as second messenger, is involved in the pathogenesis of numerous diseases within the cardiovascular, pulmonary, renal, and endocrine systems and also plays a role in neuronal, sensory, and tumor processes, drug applications might be quite broad. On the 8th International Conference on cGMP, held in Bamberg, Germany, world leading experts came together to discuss these topics. All aspects of cGMP research from the basic understanding of cGMP signaling to clinical applicability were discussed in depth. In addition, present and future therapeutic applications of cGMP-modulating pharmacotherapy were presented ( http://www.cyclicgmp.net/index.html ).

KEYWORDS:

Guanylyl cyclases; Natriuretic peptides; Nitric oxide; Phosphodiesterases; cGMP

PMID:
29018913
PMCID:
PMC5783999
DOI:
10.1007/s00210-017-1429-5
[Indexed for MEDLINE]
Free PMC Article

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