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Sci Rep. 2017 Oct 10;7(1):12887. doi: 10.1038/s41598-017-12776-8.

A new stress sensor and risk factor for suicide: the T allele of the functional genetic variant in the GABRA6 gene.

Gonda X1,2,3, Sarginson J4,5, Eszlari N6,7, Petschner P6,7,8, Toth ZG6,9,10, Baksa D6,10, Hullam G6,11, Anderson IM12, Deakin JFW12,13, Juhasz G6,7,8,10,12, Bagdy G6,7,8.

Author information

1
MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary. gonda.xenia@med.semmelweis-univ.hu.
2
Department of Psychiatry and Psychotherapy, Kutvolgyi Clinical Centre, Semmelweis University, Budapest, Hungary. gonda.xenia@med.semmelweis-univ.hu.
3
NAP-A-SE New Antidepressant Target Research Group, Semmelweis University, Budapest, Hungary. gonda.xenia@med.semmelweis-univ.hu.
4
School of Health Sciences, University of Manchester, Manchester, United Kingdom.
5
School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD, UK.
6
MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.
7
NAP-A-SE New Antidepressant Target Research Group, Semmelweis University, Budapest, Hungary.
8
Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
9
Institute of Communication Engineering, Kando Kalman Faculty of Electrical Engineering, Obuda University, Budapest, Hungary.
10
MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.
11
Department of Measurement and Information Systems, Budapest University of Technology and Economics, Budapest, Hungary.
12
Neuroscience and Psychiatry Unit, Division of Neuroscience and Experimental Psychology, University of Manchester and Manchester Academic Health Sciences Centre, Manchester, United Kingdom.
13
Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK.

Abstract

Low GABA transmission has been reported in suicide, and GABRA6 rs3219151 T allele has been associated with greater physiological and endocrine stress response in previous studies. Although environmental stress also plays a role in suicide, the possible role of this allele has not been investigated in this respect. In our present study effect of rs3219151 of GABRA6 gene in interaction with recent negative life events on lifetime and current depression, current anxiety, as well as lifetime suicide were investigated using regression models in a white European general sample of 2283 subjects. Post hoc measures for phenotypes related to suicide risk were also tested for association with rs3219151 in interaction with environmental stress. No main effect of the GABRA6 rs3219151 was detected, but in those exposed to recent negative life events GABRA6 T allele increased current anxiety and depression as well as specific elements of suicide risk including suicidal and death-related thoughts, hopelessness, restlessness and agitation, insomnia and impulsiveness as measured by the STOP task. Our data indicate that stress-associated suicide risk is elevated in carriers of the GABRA6 rs3219151 T allele with several independent markers and predictors of suicidal behaviours converging to this increased risk.

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