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Clin Infect Dis. 2017 Sep 1;65(5):827-832. doi: 10.1093/cid/cix436.

Population-Level Herd Protection of Males From a Female Human Papillomavirus Vaccination Program: Evidence from Australian Serosurveillance.

Author information

1
National Centre for Immunisation Research and Surveillance, Westmead.
2
Discipline of Paediatrics and Child Health, University of Sydney, New South Wales, Australia.
3
PPD Laboratories, Highland Heights, Kentucky.
4
National HPV Vaccination Program Register, Victorian Cytology Service, East Melbourne.
5
School of Population and Global Health, University of Melbourne, Victoria, Australia.

Abstract

Background:

Australia instituted funded female human papillomavirus (HPV) immunization in 2007, followed by a targeted male vaccination program in 2013. To date, Australia is one of only several countries with a funded male HPV immunization program. In 2012-2013, we conducted a survey of HPV seroprevalence in males to assess whether or not a herd impact of female vaccination could be observed.

Methods:

We conducted a cross-sectional study of de-identified residual diagnostic test serum samples from males aged 15-39 years from laboratories in 3 Australian states and calculated the proportion seropositive to HPV types 6, 11, 16, and 18. We compared type-specific results by age group against those from a baseline 2005 Australian HPV serosurvey.

Results:

There were decreases in proportion seropositive for every HPV type across all age groups, many statistically significant. The largest decrease was observed for HPV-11, with decreases of 8- and 9-fold for ages 20-29 and 30-39 years, respectively. Despite substantial reductions in seroprevalence, at least 9% of males were seropositive for at least 1 of the 4 HPV types.

Conclusions:

This is the first serosurvey confirming broad population-level impact in males from female HPV vaccination. Our research may assist policy makers considering implementing HPV vaccination programs.

KEYWORDS:

HPV male serosurveillance; HPV prevalence; HPV vaccination; serosurvey

PMID:
29017279
DOI:
10.1093/cid/cix436
[Indexed for MEDLINE]

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