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Biomed Pharmacother. 2017 Dec;96:313-319. doi: 10.1016/j.biopha.2017.10.017. Epub 2017 Oct 7.

Protective effect of carvacrol on acetic acid-induced colitis.

Author information

1
Department of Physiology, Federal University of Sergipe (UFS), São Cristóvão, SE, Brazil.
2
Department of Morphology, Federal University of Sergipe (UFS), São Cristóvão, SE, Brazil.
3
Department of Physiology, Federal University of Sergipe (UFS), São Cristóvão, SE, Brazil. Electronic address: enilton.camargo@pq.cnpq.br.

Abstract

The pharmacological therapy for inflammatory bowel diseases continues to be problematic, and requires new alternative options. In this study, we tested the hypothesis that carvacrol (CAR), a phenolic monoterpene with anti-inflammatory and antioxidant activities, can treat experimental colitis in mice. C57BL/6 mice (n=8/group) were subjected to intrarectal administration of acetic acid (5%) to induce colitis. Mice were pretreated with CAR (25, 50 or 100mg/kg, p.o.) every 12h for three days prior to the induction. Abdominal hyperalgesia, macroscopic and microscopic colon damage, myeloperoxidase (MPO) activity, tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels, oxidative stress markers, and antioxidant enzyme activities were evaluated. Pretreatment with all doses of CAR significantly decreased abdominal hyperalgesia and colon MPO activity and TNF-α and IL-1β levels. A reduction in macroscopic and microscopic damage (p<0.05) was observed at doses of 50 and 100mg/kg CAR. Pretreatment with CAR significantly reduced lipid peroxidation (for all doses) and increased sulfhydryl groups (at 100mg/kg). This effect was accompanied by a significant increase in catalase, superoxide dismutase, and glutathione peroxidase activities. These findings indicate that CAR protected mice from acetic acid-induced colitis by reducing inflammatory, nociceptive, and oxidative damages.

KEYWORDS:

Carvacrol; Colitis; Inflammation; Nociception; Oxidative stress; Terpenes

PMID:
29017143
DOI:
10.1016/j.biopha.2017.10.017
[Indexed for MEDLINE]

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