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Nature. 1988 Aug 11;334(6182):494-8.

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

Author information

1
Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California 92037.

Abstract

A nuclear protein, CREB, has been isolated from rat brain and shown to stimulate transcription of the cyclic AMP-responsive gene somatostatin as a dimer. Biochemical analysis suggests that dimerization and transcriptional efficacy of CREB protein in vitro are regulated by phosphorylation. These findings demonstrate that cellular signals can modulate gene expression by regulating the covalent modification of pre-existing nuclear factors.

PMID:
2900470
DOI:
10.1038/334494a0
[Indexed for MEDLINE]

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