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Lancet. 1988 Aug 27;2(8609):471-5.

Use of recombinant granulocyte-macrophage colony stimulating factor in the Brazil radiation accident.

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Hospital Marcilio Dias, Rio de Janeiro, Brazil.


8 patients with bone marrow failure after a caesium-137 radiation accident were treated with recombinant human granulocyte-macrophage colony stimulating factor (rHuGM-CSF). The 7 who were evaluable had prompt increases in granulocytes and bone marrow cellularity. 2 patients died of radiation toxicity and haemorrhage and 2 of bacterial sepsis acquired before the start of rHuGM-CSF treatment. 4 patients survive, including 2 who were treated early and never became infected. This therapeutic approach to radiation-induced granulocytopenia may therefore be useful after radiation and nuclear accidents.

[Indexed for MEDLINE]

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