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J Vis Exp. 2017 Sep 27;(127). doi: 10.3791/55987.

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment.

Author information

1
Neuroscience Research Institute & Department of Physiology, College of Medicine, Korea University.
2
Department of Pharmaceutics and Biotechnology, College of Medical Engineering, Konyang University.
3
Division of Biological Science and Technology, Science and Technology College, Yonsei University Wonju Campus.
4
Neuroscience Research Institute & Department of Physiology, College of Medicine, Korea University; hsna@korea.ac.kr.

Abstract

Atopic dermatitis is chronically relapsing pruritic eczema and prevails around the world especially in developed countries. Complex interactions between genetic and environmental factors are known to play an important role in the pathophysiology of atopic dermatitis. However, we still lack a detailed picture of the pathogenesis of this disease. Thus, it is of importance to develop appropriate animal models for elucidating the progression of atopic dermatitis. Moreover, investigating the effect of environmental factors such as air pollutants on atopic dermatitis expands understanding of the disease. Here, we describe a method for inducing atopic dermatitis in rats with neonatal capsaicin treatment and a protocol for exposure of a constant concentration of formaldehyde to rats to reveal effects on the development of atopic dermatitis in infantile and adolescent periods. These protocols have been successfully applied to several experiments and can be used for other substances.

PMID:
28994767
PMCID:
PMC5752336
[Available on 2019-09-27]
DOI:
10.3791/55987
[Indexed for MEDLINE]

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