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Nat Commun. 2017 Oct 9;8(1):806. doi: 10.1038/s41467-017-00920-x.

Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6.

Author information

1
St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy, VIC, 3065, Australia.
2
Department of Neurosurgery, Kyungpook National University Hospital, 130 Dongdukro, Jung-gu, Daegu, 41944, Republic of Korea.
3
Department of Medicine at St. Vincent's Hospital, University of Melbourne, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.
4
Division of Clinical Pharmacology, Vanderbilt University, 2215 Garland Avenue, 1255B MRB IV, Nashville, TN, 37212, USA.
5
Department of Andrology, ANZAC Research Institute, University of Sydney, 3 Hospital Road, Concord, NSW, 2139, Australia.
6
St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy, VIC, 3065, Australia. nsims@svi.edu.au.
7
Department of Medicine at St. Vincent's Hospital, University of Melbourne, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia. nsims@svi.edu.au.

Abstract

Long bone strength is determined by its outer shell (cortical bone), which forms by coalescence of thin trabeculae at the metaphysis (corticalization), but the factors that control this process are unknown. Here we show that SOCS3-dependent cytokine expression regulates bone corticalization. Young male and female Dmp1Cre.Socs3 f/f mice, in which SOCS3 has been ablated in osteocytes, have high trabecular bone volume and poorly defined metaphyseal cortices. After puberty, male mice recover, but female corticalization is still impaired, leading to a lasting defect in bone strength. The phenotype depends on sex-steroid hormones: dihydrotestosterone treatment of gonadectomized female Dmp1Cre.Socs3 f/f mice restores normal cortical morphology, whereas in males, estradiol treatment, or IL-6 deletion, recapitulates the female phenotype. This suggests that androgen action promotes metaphyseal corticalization, at least in part, via IL-6 signaling.The strength of long bones is determined by coalescence of trabeculae during corticalization. Here the authors show that this process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones.

PMID:
28993616
PMCID:
PMC5634449
DOI:
10.1038/s41467-017-00920-x
[Indexed for MEDLINE]
Free PMC Article

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