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J Neurogastroenterol Motil. 2017 Oct 30;23(4):569-577. doi: 10.5056/jnm17033.

Nationwide Multicenter Study for Overlaps of Common Functional Gastrointestinal Disorders in Korean Patients With Constipation.

Author information

1
Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
2
Inje University College of Medicine, Busan, Korea.
3
Pusan National University School of Medicine, Busan, Korea.
4
Seoul National University College of Medicine, Seoul, Korea.
5
Dankook University College of Medicine, Cheonan, Chungnam, Korea.
6
Jeju National University School of Medicine, Jeju, Korea.
7
Catholic University of Daegu School of Medicine, Daegu, Korea.
8
Wonkwang University School of Medicine, Iksan, Jeonbuk, Korea.
9
Department of Internal Medicine and Wonkwang Digestive Disease Research Institute, Wonkwang University Sanbon Hospital, Gunpo, Gyeonggi-do, Korea.
10
Kyungpook National University School of Medicine, Daegu, Korea.
11
Soonchunhyang University College of Medicine, Seoul, Korea.
12
Yeungnam University College of Medicine, Daegu, Korea.
13
National Medical Center, Seoul, Korea.
14
Chungnam National University School of Medicine, Daejeon, Korea.
15
Hallym University College of Medicine, Chuncheon, Gangwon-do, Korea.
16
Kosin University College of Medicine, Busan, Korea.
17
Yonsei University College of Medicine, Seoul, Korea.
18
Chonnam National University Medical School, Gwangju, Korea.
19
Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

Background/Aims:

In spite of increased concerns about the overlaps among the various functional gastrointestinal disorders (FGIDs), studies for the overlap between constipation and other common FGIDs are rare. Therefore, we investigated the patterns of overlaps between constipation and other common FGIDs.

Methods:

This study was designed as a prospective nationwide multi-center questionnaire study using Rome III questionnaires for functional dyspepsia (FD), irritable bowel syndrome (IBS), and functional constipation (FC), as well as various questionnaires about patients' information, degree of symptoms, and quality of life. For the evaluation of gastroesophageal reflux disease (GERD), GERD-Q was used.

Results:

From 19 centers, 759 patients with constipation were enrolled. The proportions of FC and IBS subtypes of constipation (IBS-C) were 59.4% and 40.6%, respectively. Among them, 492 (64.8%) showed no overlap. One hundred and thirty-six patients (17.9%) presented overlapping GERD, and 80 patients (10.5%) presented overlapping FD. Fifty one (6.7%) of patients were overlapped by both GERD and FD. Coincidental herniated nucleus pulposus (HNP) (P = 0.026) or pulmonary diseases (P = 0.034), reduced fiber intake (P = 0.013), and laxative use (P < 0.001) independently affected the rate of overlaps. These overlapping conditions negatively affected the constipation-associated quality of life, general quality of life, and degree of constipation.

Conclusions:

The overlap of GERD or FD was common in patients with constipation. Coincidental HNP or pulmonary diseases, reduced fiber intake, and laxatives use were found to be independent associated factors for overlapping common FGIDs in Korean patients with constipation.

KEYWORDS:

Constipation; Dyspepsia; Gastroesophageal reflux; Overlapping

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