Format

Send to

Choose Destination
Soc Cogn Affect Neurosci. 2017 Sep 1;12(9):1428-1436. doi: 10.1093/scan/nsx072.

Nucleus accumbens shell moderates preference bias during voluntary choice behavior.

Author information

1
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
2
Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA.
3
Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea.

Abstract

The nucleus accumbens (NAc) shell lies anatomically at a critical intersection within the brain's reward system circuitry, however, its role in voluntary choice behavior remains unclear. Rats with electrolytic lesions in the NAc shell were tested in a novel foraging paradigm. Over a continuous two-week period they freely chose among four nutritionally identical but differently flavored food pellets by pressing corresponding levers. We examined the lesion's effects on three behavioral dynamics components: motivation (when to eat), preference bias (what to choose) and persistence (how long to repeat the same choice). The lesion led to a marked increase in the preference bias: i.e., increased selection of the most-preferred choice option, and decreased selection of the others. We found no effects on any other behavioral measures, suggesting no effect on motivation or choice persistence. The results implicate the NAc shell in moderating the instrumental valuation process by inhibiting excessive bias toward preferred choice options.

KEYWORDS:

foraging decision-making behavior; inhibitory control; mesolimbic reward pathway; motivation; neurobiology of reward valuation

PMID:
28992274
PMCID:
PMC5629817
DOI:
10.1093/scan/nsx072
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center