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Med Mycol. 2018 Apr 1;56(suppl_1):153-164. doi: 10.1093/mmy/myx061.

Closing the mycetoma knowledge gap.

Author information

1
ErasmusMC, Department of Medical Microbiology and Infectious Diseases, Wytemaweg 80, 3015 CE, Rotterdam, The Netherlands.
2
Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.
3
Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
4
Laboratorio de MicologĂ­a, Hospital Independencia, Santiago del Estero, Argentina.
5
General Hospital of Mexico, Department of Mycology, Dermatology Service, Mexico City, Mexico.
6
Rotterdam Centre for Tropical Medicine, Rotterdam, The Netherlands.

Abstract

On 28th May 2016, mycetoma was recognized as a neglected tropical disease by the World Health Organization. This was the result of a 4-year journey starting in February 2013 with a meeting of global mycetoma experts. Knowledge gaps were identified and included the incidence, prevalence, and mapping of mycetoma; the mode of transmission; the development of methods for early diagnosis; and better treatment. In this review, we review the road to recognition, the ISHAM working group meeting in Argentina, and we address the progress made in closing the knowledge gaps since 2013. Progress included adding another 9000 patients to the literature, which allowed us to update the prevalence map on mycetoma. Furthermore, based on molecular phylogeny, species names were corrected and four novel mycetoma causative agents were identified. By mapping mycetoma causative agents an association with Acacia trees was found. For early diagnosis, three different isothermal amplification techniques were developed, and novel antigens were discovered. To develop better treatment strategies for mycetoma patients, in vitro susceptibility tests for the coelomycete agents of black grain mycetoma were developed, and the first randomized clinical trial for eumycetoma started early 2017.

PMID:
28992217
DOI:
10.1093/mmy/myx061
[Indexed for MEDLINE]

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