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Br J Dermatol. 2018 May;178(5):1196-1198. doi: 10.1111/bjd.16045. Epub 2018 Feb 23.

Low-dose naltrexone: a novel treatment for Hailey-Hailey disease.

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1
Department of Dermatology, Wing D, Belfast City Hospital, Lisburn Rd, Belfast, BT9 7AB, U.K.

Abstract

Hailey-Hailey disease (chronic benign familial pemphigus) is a rare inherited dermatosis typically characterized by erosions at intertriginous sites preceded by minor trauma or stress. We report a case of treatment-resistant Hailey-Hailey disease having failed topical and oral steroids, prophylactic aciclovir and doxycycline, and systemic therapies including dapsone, acitretin and ciclosporin. Low-dose naltrexone 4·5 mg once daily was commenced following an incidental benefit in this patient's similarly affected sister. The clinical and psychological response to date has been considerable.

PMID:
28991360
DOI:
10.1111/bjd.16045

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