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Org Biomol Chem. 2017 Oct 25;15(41):8700-8704. doi: 10.1039/c7ob02205k.

Unprecedented 22,26-seco physalins from Physalis angulata and their anti-inflammatory potential.

Author information

1
Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. fengqiu20070118@163.com.

Abstract

Two novel physalins, including a 22,26-seco physalin, physalin X (1), and a 11,15-cyclo-9(10),14(17),22(26)-triseco physalin with an unprecedented aromatic ring, aromaphysalin B (2), were isolated from Physalis angulata L. Their structures were determined by IR, UV, HRESIMS, and 2D NMR spectra as well as theoretical calculations. Compounds 1 and 2 exhibited inhibitory activities on NO production with IC50 values of 68.50 and 29.69 μM, respectively. A plausible biosynthetic pathway for 2 is also discussed.

PMID:
28991309
DOI:
10.1039/c7ob02205k
[Indexed for MEDLINE]

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