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Gac Med Mex. 2017;153(4):459-465. doi: 10.24875/GMM.17002574.

Platelet-rich plasma and its effect in bone regeneration in mandibular fractures. Controlled clinical trial

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Servicio de Cirugía Maxilofacial, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social. Guadalajara, Jal., México.
2
Servicio de Cirugía Plástica y Reconstructiva, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social. Guadalajara, Jal., México.
3
Unidad de Investigación Biomédica 02, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social. Guadalajara, Jal., México.
4
Instituto de Investigación en Odontología, Departamento de Clínicas Odontológicas Integrales CUCS, Universidad de Guadalajara, Guadalajara, Jal., México.

Abstract

in English, Spanish

Background:

Currently there is great interest in developing clinical applications of platelet-rich plasma to enhance bone repair.

Aim:

To assess bone regeneration in mandibular fractures, with the application of this adjuvant.

Methods:

Twenty patients with mandibular fractures were included in a randomized clinical trial. Patients of the experimental group (n = 10) were submitted to internal fracture reduction and administration of platelet-rich plasma, and patients of the control group (n = 10) were submitted to the same surgical procedure without plasma application. Radiologic assessment was made before and at 1 and 3 months after surgery. X-rays were digitalized for analyze intensity and density as reflection of bone regeneration.

Results:

The average age was 32 ± 11.3 years and 31.2 ± 8.48 years respectively (p = 0.76). The radiographic intensity and density in the experimental group at the 1st and 3rd month were higher in contrast to the control group (p < 0.005). Bone regeneration time was 3.7 ± 0.48 and 4.5 ± 0.52 weeks respectively (p = 0.002). There was no morbidity related to the application of the platelet-rich plasma.

Conclusion:

The platelet-rich plasma increased the bone intensity and density in the fracture trace allowing bone regeneration and recovery in shorter time than patients in which it was not used.

KEYWORDS:

Bone regeneration; Mandibular fractures; Platelet-rich plasma

PMID:
28991280
DOI:
10.24875/GMM.17002574
[Indexed for MEDLINE]
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