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Soc Neurosci. 2018 Dec;13(6):688-700. doi: 10.1080/17470919.2017.1386126. Epub 2017 Oct 9.

Neuroanatomical correlates of emotion-processing in children with unilateral brain lesion: A preliminary study of limbic system organization.

Author information

1
a Laboratory for Cognitive Neuroscience , Salk Institute for Biological Studies , La Jolla , CA , USA.
2
b Institute of Child Development , University of Minnesota , Minneapolis , MN , USA.
3
c San Diego State University/University of California, San Diego Joint Doctoral Program in Language and Communicative Disorders , San Diego , CA , USA.
4
d Center for Multimodal Imaging and Genomics , University of California San Diego , La Jolla , CA , USA.
5
e Department of Radiology , University of California, San Diego School of Medicine , La Jolla , CA , USA.
6
f Department of Neurosciences , University of California, San Diego School of Medicine , La Jolla , CA , USA.

Abstract

In this study, MRI and DTI were employed to examine subcortical volume and microstructural properties (FA, MD) of the limbic network, and their relationships with affect discrimination in 13 FL (6 right FL, M = 10.17 years; 7 left FL; M = 10.09) and 13 typically-developing children (TD; M = 10.16). Subcortical volume of the amygdala, hippocampus and thalamus and FA and MD of the fornix and anterior thalamic radiation (ATR) were examined. Results revealed no group differences across emotion-perception tasks or amygdalar volume. However, contrasting neuroanatomical patterns were observed in right versus left FL youth. Right FL participants showed increased left hippocampal and thalamic volume relative to left FL participants; whereas, the latter group showed increased right thalamic volume. DTI findings also indicated right FL children show greater MD of right fornix than other groups, whereas, left FL youth showed greater MD of left fornix. Right FL youth also showed lower FA of right fornix than left FL children, whereby the latter showed greater FA of left fornix and ATR. Differential associations between DTI indices and auditory/visual emotion-perception were observed across FL groups. Findings indicate diverging brain-behavioral relationships for emotion-perception among right and left FL children.

KEYWORDS:

DTI; Focal lesion; anterior thalamic radiation; emotion perception; fornix; limbic system

PMID:
28990866
PMCID:
PMC6117211
[Available on 2019-12-01]
DOI:
10.1080/17470919.2017.1386126
[Indexed for MEDLINE]

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