Send to

Choose Destination
Acta Otolaryngol. 2018 Feb;138(2):153-158. doi: 10.1080/00016489.2017.1380313. Epub 2017 Oct 9.

Utilization patterns of systemic corticosteroid use for chronic rhinosinusitis.

Author information

a Department of Otolaryngology , Harvard Medical School , Boston , MA , USA.
b Department of Otolaryngology , Massachusetts Eye and Ear Infirmary , Boston , MA , USA.
c Division of Otolaryngology , Beth Israel Deaconess Medical Center , Boston , MA , USA.
d Department of Otolaryngology and Communication Enhancement , Boston Children's Hospital , Boston , MA , USA.



We sought to characterize the utilization pattern and factors associated with use of systemic corticosteroids for CRS.


This was a cross-sectional study of 236 participants with CRS who were prospectively recruited. Participants reported the number of CRS-related oral corticosteroid courses taken in the last year. Baseline CRS symptomatology was measured using the 22-item Sinonasal Outcome Test (SNOT-22) and SNOT-22 sleep, nasal, otologic/facial pain and emotional subdomain scores. Clinical and demographic characteristics were also collected. Association was determined between patient characteristics and oral corticosteroid use in the last year for CRS.


Sleep (p = .026), nasal (p < .001) and otologic/facial pain (p = .022) SNOT-22 subdomain scores, and nasal polyps (p = .007) were associated with CRS-related oral corticosteroid use. In study participants without polyps, past CRS-related oral corticosteroid use was associated with sleep (adjusted OR = 1.56, 95%CI: 1.01-2.40, p = .043), otologic/facial pain (adjusted OR = 1.65, 95%CI: 1.09-2.51, p = .019) and nasal subdomain scores (adjusted OR = 1.59, 95%CI: 1.01-2.51, p = .047). In study participants with polyps, past CRS-related oral corticosteroid use was only associated with the nasal subdomain score (adjusted OR = 2.20, 95%CI: 1.40-3.45, p = .001).


Past CRS-related oral corticosteroid use was associated with increased baseline severity of specific symptoms, which were different depending on the presence of polyps.


Chronic rhinosinusitis; SNOT-22; emotional symptoms; facial pain; nasal symptoms; oral corticosteroids; otologic symptoms; polyps; principal component analysis; sleep

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center