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Obstet Gynecol Sci. 2017 Sep;60(5):477-480. doi: 10.5468/ogs.2017.60.5.477. Epub 2017 Sep 18.

BRCA1-mutated ovarian cancer with skin metastasis: a case report.

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Department of Obstetrics and Gynecology, Dong-A University College of Medicine, Busan, Korea.
Department of Pathology, Dong-A University College of Medicine, Busan, Korea.


The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that BRCA1- and BRCA2-mutated OCs are associated with better prognosis than sporadic OCs. However, information about the patterns and clinical course of the metastatic spread of BRCA-mutated OCs is limited. Herein, we describe a case of OC with a BRCA1 mutation and skin metastases in a 49-year-old patient, which to the best of our knowledge has not been reported previously.


BRCA mutation; Ovarian neoplasms; Skin metastases

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