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Obstet Gynecol Sci. 2017 Sep;60(5):477-480. doi: 10.5468/ogs.2017.60.5.477. Epub 2017 Sep 18.

BRCA1-mutated ovarian cancer with skin metastasis: a case report.

Author information

1
Department of Obstetrics and Gynecology, Dong-A University College of Medicine, Busan, Korea.
2
Department of Pathology, Dong-A University College of Medicine, Busan, Korea.

Abstract

The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that BRCA1- and BRCA2-mutated OCs are associated with better prognosis than sporadic OCs. However, information about the patterns and clinical course of the metastatic spread of BRCA-mutated OCs is limited. Herein, we describe a case of OC with a BRCA1 mutation and skin metastases in a 49-year-old patient, which to the best of our knowledge has not been reported previously.

KEYWORDS:

BRCA mutation; Ovarian neoplasms; Skin metastases

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