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Chem Sci. 2017 Sep 1;8(9):6555-6560. doi: 10.1039/c7sc01692a. Epub 2017 Jul 26.

Light-responsive paper strips as CO-releasing material with a colourimetric response.

Author information

1
Institute for Inorganic and Analytical Chemistry (IAAC) , Friedrich Schiller University Jena , Humboldtstr. 8 , D-07743 Jena , Germany . Email: alexander.schiller@uni-jena.de.
2
Leibniz Institute of Photonic Technology , Albert-Einstein-Str. 9 , D-07745 Jena , Germany.
3
Center for Sepsis Control and Care (CSCC) , Jena University Hospital , Am Klinikum 1 , D-07747 Jena , Germany.
4
Institute of Physical Chemistry (IPC) , Abbe Center for Photonics Friedrich Schiller University Jena , Helmholtzweg 4 , D-07743 Jena , Germany.

Abstract

Carbon monoxide (CO) is known for its multifaceted role in human physiology, and molecules that release CO in a controlled way have been proposed as therapeutic drugs. In this work, a light-responsive CO-releasing molecule (CORM-Dabsyl) showed a strong colourimetric response upon photochemical CO-release, owing to the tight conjugation of a Mn(i) tricarbonyl centre to a dabsyl chromophoric ligand (L). Whereas the complex was very stable in the dark in nitrogen-purged aqueous media, CO-release was effectively triggered using 405 nm irradiation. CORM-Dabsyl, L and the inactive product iCORM-Dabsyl have been investigated by DFT and TD-DFT calculations. Only mild toxicity of CORM-Dabsyl was observed against LX-2 and HepaRG® human cell lines (IC50 ∼ 30 μM). Finally, to develop a CO storage and release material that is readily applicable to therapeutic situations, CORM-Dabsyl was loaded on low-cost and easily disposable paper strips, from which the light triggered CO-release was conveniently visible with the naked eye.

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