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Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):189-196. doi: 10.1016/j.bbadis.2017.10.011. Epub 2017 Oct 6.

IgE induces hypotension in asthma mice by down-regulating vascular NCX1 expression through activating MiR-212-5p.

Author information

1
State Key Laboratory of Medical Molecular Biology, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing,China.
2
Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA.
3
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, China.
4
State Key Laboratory of Medical Molecular Biology, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing,China. Electronic address: wangjing@ibms.pumc.edu.cn.

Abstract

Immunoglobulin E (IgE) has been suggested as a risk factor for allergy-induced low blood pressure, which has not been well explained in molecular details. Our current study shows a novel mechanism involving IgE, FcɛR1, miRNA-212-5p (miR-212-5p), and sodium/calcium exchanger protein 1(NCX1) for asthma to induce hypotension. In arterial smooth muscle cells, IgE up-regulated miR212-5p via its receptor FcɛR1, which resulted in down-regulation of NCX1 that is a regulating factor for blood pressure. In mice, asthma induced hypotension by interfering vasoconstrictive function; knockout of FcɛR1 kept the asthmatic mice from developing hypotension; knock-down of miR-212-5p in asthmatic mice resulted in a significant restoration of blood pressure. In human, asthma and IgE were positively correlated with hypotension in cohort study on NIH epidemiological data. This study suggests a novel therapeutic target (miR-212-5p) for treatment of asthma-induced hypotension.

KEYWORDS:

Asthma; FcεR1(−/−); Hypotension; IgE

PMID:
28988887
DOI:
10.1016/j.bbadis.2017.10.011
[Indexed for MEDLINE]
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