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Vaccine. 1988 Apr;6(2):151-4.

Safe, live Vibrio cholerae vaccines?

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Department of Microbiology and Immunology, University of Tennessee, Memphis 38163.


Mutants of Vibrio cholerae defective in intestinal colonization have been constructed. Characterization of these mutants has led to the identification of a gene cluster involved in the assembly of a pilus colonization factor called TCP. The tcp operon has been cloned and strains of V. cholerae have been constructed that overproduce this pilus and the B subunit of cholera toxin. Together these studies may contribute to the eventual construction of efficient live and killed, oral cholera vaccines.

[Indexed for MEDLINE]

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