Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuropharmacology. 2017 Oct 5. pii: S0028-3908(17)30466-5. doi: 10.1016/j.neuropharm.2017.09.038. [Epub ahead of print]

Food for thought: Leptin regulation of hippocampal function and its role in Alzheimer's disease.

Author information

1
Division of Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom.
2
Division of Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom. Electronic address: j.z.harvey@dundee.ac.uk.

Abstract

Accumulating evidence indicates that diet and body weight are important factors associated with Alzheimer's disease (AD), with a significant increase in AD risk linked to mid-life obesity, and weight loss frequently occurring in the early stages of AD. This has fuelled interest in the hormone leptin, as it is an important hypothalamic regulator of food intake and body weight, but leptin also markedly influences the functioning of the hippocampus; a key brain region that degenerates in AD. Increasing evidence indicates that leptin has cognitive enhancing properties as it facilitates the cellular events that underlie hippocampal-dependent learning and memory. However, significant reductions in leptin's capacity to regulate hippocampal synaptic function occurs with age and dysfunctions in the leptin system are associated with an increased risk of AD. Moreover, leptin is a potential novel target in AD as leptin treatment has beneficial effects in various models of AD. Here we summarise recent advances in leptin neurobiology with particular focus on regulation of hippocampal synaptic function by leptin and the implications of this for neurodegenerative disorders like AD.

KEYWORDS:

AMPA receptor trafficking; Alzheimer's disease; Excitatory synaptic transmission; Hippocampus; Leptin; Synaptic plasticity

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center