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Cancer Lett. 2017 Dec 28;411:82-89. doi: 10.1016/j.canlet.2017.09.049. Epub 2017 Oct 5.

Autophagy in the "inflammation-carcinogenesis" pathway of liver and HCC immunotherapy.

Author information

1
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: 512319481@qq.com.
2
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: 13649289776@163.com.
3
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: jinglee911@126.com.
4
Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: fxclaret@mdanderson.org.
5
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: drliqing@126.com.
6
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: tiantao0607@163.com.
7
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: elva_0209@126.com.
8
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: zopor@163.com.
9
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: jiangli8499@163.com.
10
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: 13572101611@163.com.
11
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: nankj@163.com.
12
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: luyi169@126.com.
13
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: guohuihappy97@163.com.

Abstract

Autophagy plays a dual role in many types of cancer, such as hepatocellular carcinoma (HCC). Autophagy seems to be inhibited and functions as a tumor-suppression mechanism in the "inflammation-carcinogenesis" pathway of the liver, including hepatitis B virus and hepatitis C virus, alcoholic steatohepatitis and non-alcoholic steatohepatitis related HCC. However, in established tumors, autophagy plays a tumor-promoting role. Because of the varied function of autophagy in HCC, we hypothesized p62 as a marker to evaluate the autophagic level. Moreover, autophagy is critical in antigen presentation and homeostasis of immune cells and tumor microenvironment. Understanding the intricate relationships of autophagy, inflammation, and immunity provides us with new insights into HCC immunotherapy.

KEYWORDS:

Autophagy; Hepatocellular carcinoma; Immunotherapy; Inflammation

PMID:
28987386
DOI:
10.1016/j.canlet.2017.09.049
[Indexed for MEDLINE]

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