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Bone. 2018 Apr;109:12-21. doi: 10.1016/j.bone.2017.09.019. Epub 2017 Oct 5.

Heterotopic ossification and the elucidation of pathologic differentiation.

Author information

1
Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
2
Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, USA.
3
Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, USA; Department of Surgery, Uniformed Services University of the Health Sciences & the Walter Reed National Military Medical Center, Bethesda, MD, USA.
4
School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
5
Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA. Electronic address: blevi@med.umich.edu.

Abstract

Tissue regeneration following acute or persistent inflammation can manifest a spectrum of phenotypes ranging from the adaptive to the pathologic. Heterotopic Ossification (HO), the endochondral formation of bone within soft-tissue structures following severe injury serves as a prominent example of pathologic differentiation; and remains a persistent clinical issue incurring significant patient morbidity and expense to adequately diagnose and treat. The pathogenesis of HO provides an intriguing opportunity to better characterize the cellular and cell-signaling contributors to aberrant differentiation. Indeed, recent work has continued to resolve the unique cellular lineages, and causative pathways responsible for ectopic bone development yielding promising avenues for the development of novel therapeutic strategies shown to be successful in analogous animal models of HO development. This review details advances in the understanding of HO in the context of inciting inflammation, and explains how these advances inform the current standards of diagnosis and treatment.

KEYWORDS:

Bone morphogenetic protein receptors; Ectopic bone; Inflammation

PMID:
28987285
DOI:
10.1016/j.bone.2017.09.019
[Indexed for MEDLINE]

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