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Lancet. 1988 Jul 9;2(8602):72-4.

Enhanced tumour necrosis factor and interleukin-1 in fulminant hepatic failure.

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1
First Department of Internal Medicine, Gifu University School of Medicine, Japan.

Abstract

Sepsis and endotoxaemia are common in fulminant hepatic failure (FHF) and may contribute to multisystem disease in such patients. Tumour necrosis factor (TNF) is a probable mediator of endotoxic shock and infusion of this monokine into animals causes multi-organ failure that shares features with FHF. In patients with FHF, TNF production was increased and correlated closely with activity of interleukin-1, another cytokine that is released by monocytes/macrophages in response to infection and endotoxin and is produced in increased quantities in FHF. Interleukin-2 activity was impaired in FHF and correlated negatively with TNF production.

PMID:
2898700
[Indexed for MEDLINE]
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