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Chembiochem. 2017 Dec 5;18(23):2295-2297. doi: 10.1002/cbic.201700533. Epub 2017 Nov 2.

Electron Bifurcation Makes the Puzzle Pieces Fall Energetically into Place in Methanogenic Energy Conservation.

Author information

1
Biosciences Center, National Renewable Energy Laboratory, 15013 Denver W Parkway, Golden, CO, 80401, USA.
2
Institute of Biological Chemistry, Washington State University, Pullman, WA, 99164, USA.

Abstract

Elaborate arrays of iron-sulfur clusters link active sites via a flavin that bifurcates electrons through two energetically independent paths. The structure of the heterodisulfide reductase provides insight into how methanogens conserve energy through coupling hydrogen oxidation to coordinated exergonic heterodisulfide and endergonic ferredoxin reduction in an overall thermodynamically favorable reaction.

KEYWORDS:

electron bifurcation; energy conservation; flavin; iron-sulfur cluster; methanogenesis

PMID:
28986941
DOI:
10.1002/cbic.201700533
[Indexed for MEDLINE]

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