Format

Send to

Choose Destination
Protein Cell. 2018 Jan;9(1):63-73. doi: 10.1007/s13238-017-0473-8. Epub 2017 Oct 6.

IgG Fc engineering to modulate antibody effector functions.

Author information

1
Genentech, Antibody Engineering, South San Francisco, CA, 94080, USA.
2
Genentech, Antibody Engineering, South San Francisco, CA, 94080, USA. brezski.randall@gene.com.

Abstract

Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions. The majority of approved recombinant monoclonal antibody therapies are of the human IgG1 subclass, which can engage both humoral and cellular components of the immune system. The wealth of information generated about antibodies has afforded investigators the ability to molecularly engineer antibodies to modulate effector functions. Here, we review various antibody engineering efforts intended to improve efficacy and safety relative to the human IgG isotype. Further, we will discuss proposed mechanisms by which engineering approaches led to modified interactions with immune components and provide examples of clinical studies using next generation antibodies.

KEYWORDS:

Fc engineering; Fc gamma receptor; antibody-dependent cell-mediated cytotoxicity; antibody-dependent cellular phagocytosis; complement-dependent cytotoxicity; monoclonal antibody; neonatal Fc receptor

PMID:
28986820
PMCID:
PMC5777978
DOI:
10.1007/s13238-017-0473-8
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center