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J Leukoc Biol. 2017 Dec;102(6):1333-1345. doi: 10.1189/jlb.3RU0417-148RR. Epub 2017 Oct 6.

The role of halofuginone in fibrosis: more to be explored?

Author information

1
Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China; and.
2
Xiangya School of Stomatology, Central South University, Changsha, Hunan Province, China.
3
Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China; and gaoyijun1165@163.com.

Abstract

Fibrosis, which can be defined as an abnormal or excessive accumulation of extracellular matrix (ECM), particularly fibrillar collagens, is a key driver of progressive organ dysfunction in many inflammatory and metabolic diseases, including idiopathic pulmonary fibrosis (IPF), cirrhosis, nephropathy, and oral submucous fibrosis (OSF). It has been estimated to contribute to ∼45% of deaths in the developed world. Therefore, agents that target specific fibrotic pathways, with the consequence of slowing, arresting, or even reversing the progression of tissue fibrogenesis, are urgently needed. 7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone (halofuginone), an analog of febrifugine, which specifically targets the pathogenesis of ECM proteins, inhibits tissue fibrosis and regeneration and even affects the development of tumors in various tissues. Four modes of actions of halofuginone against fibrosis have been presented: 1) Inhibition of mothers against decapentaplegic homolog 3 (Smad3) phosphorylation downstream of the TGF-β signaling pathway, 2) reduction of collagen amounts, 3) decreases in ECM protein, and 4) selective prevention of Th17 cell differentiation. In this review, we will mainly focus on the rationale for halofuginone against fibrosis.

KEYWORDS:

TGF-β; Th17; collagen; extracellular matrix; myofibroblast

PMID:
28986385
DOI:
10.1189/jlb.3RU0417-148RR
[Indexed for MEDLINE]

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