Format

Send to

Choose Destination
Pharmacol Res. 2018 Feb;128:80-87. doi: 10.1016/j.phrs.2017.09.024. Epub 2017 Oct 3.

New perspectives in cancer: Modulation of lipid metabolism and inflammation resolution.

Author information

1
Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131 Naples, Italy; Institute of Endocrinology and Experimental Oncology (IEOS) "G. Salvatore", CNR, 80131 Naples, Italy.
2
Department of Molecular Medicine and Medical Biotechnology (DMMBM), University of Naples Federico II, 80131 Naples, Italy.
3
Department of Chemical Sciences, University of Naples "Federico II", Via Cinthia, Naples, Italy.
4
Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131 Naples, Italy.
5
Institute of Endocrinology and Experimental Oncology (IEOS) "G. Salvatore", CNR, 80131 Naples, Italy; Department of Molecular Medicine and Medical Biotechnology (DMMBM), University of Naples Federico II, 80131 Naples, Italy. Electronic address: rosmelil@unina.it.

Abstract

Inflammation is considered an enabling feature of cancer. Besides the persistence of inflammatory stimuli, also defective mechanisms of resolution can lead to chronic inflammation. Inflammation resolution is an active process controlled by lipidic specialized pro-resolving mediators (SPMs), derived from ω-3 or ω-6 essential polyunsaturated fatty acids (PUFA) through the activity of lipoxygenases (ALOX5 and 15). Thus, a lack or defect in resolution mechanisms may affect cancer development and progression by prolonging inflammation. Components of pro-resolving pathways (PUFA, enzymes, or SPMs) have been reported to modulate various cancer features by affecting both cancer cells and cancer-associated stroma. Here, we will review the most important mechanisms by which SPMs, ω-3/6 PUFA, and ALOXs affect cancer biology, paying particular attention to their role in the inhibition of inflammation and angiogenesis, two of the most important hallmarks of cancer. The collection of these results may suggest novel perspectives in cancer management based on the modulation of lipid metabolism and the production of SPMs.

KEYWORDS:

Angiogenesis; Cancer; Formyl peptide receptors; Inflammation; Pro-resolving pathways

PMID:
28986132
DOI:
10.1016/j.phrs.2017.09.024

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center