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Phytochemistry. 2017 Dec;144:226-232. doi: 10.1016/j.phytochem.2017.09.021. Epub 2017 Oct 3.

Triterpenes derived from hydrolyzate of total Gynostemma pentaphyllum saponins with anti-hepatic fibrosis and protective activity against H2O2-induced injury.

Author information

1
Department of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
2
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; School of Life Science, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
3
Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
4
Department of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: zyq4885@126.com.

Abstract

Gynostemma pentaphyllum is a popular functional food, and it is also used as a traditional medicine in Asia. In this study, five previously undescribed triterpenes, gypensapogenin M, gypensapogenin N, gypensapogenin O, gypensapogenin P, and gypensapogenin Q, together with five known compounds were isolated from the hydrolyzate of total G. pentaphyllum saponins. The bioassay data showed that all the triterpenes exhibited significant protective activity against H2O2-induced myocardial cell injury and anti-hepatic fibrosis activity. Taken together, the discovery of these triterpenes from the hydrolyzate of total G. pentaphyllum saponins expands its use as a functional food for preventing myocardial injury and liver fibrosis.

KEYWORDS:

Anti-hepatic fibrosis activity; Cardiomyocytes oxidative injury; Gynostemma pentaphyllum

PMID:
28985570
DOI:
10.1016/j.phytochem.2017.09.021
[Indexed for MEDLINE]

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