Format

Send to

Choose Destination
Cell. 2017 Oct 5;171(2):456-469.e22. doi: 10.1016/j.cell.2017.09.020.

Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism.

Author information

1
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA; College of Medicine, Penn State University, Hershey, PA, 17033, USA.
2
Center for Neural Science, New York University, NY, 10003, USA.
3
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.
4
Healthcare Technology Innovation Centre, IIT Madras, Chennai, India.
5
Institute of Brain Sciences, State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
6
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA; Program in Neuroscience and Medical Scientist Training Program, Stony Brook University, Stony Brook, NY 11790, USA.
7
Center for Neural Science, New York University, NY, 10003, USA; NYU-ECNU Institute of Brain and Cognitive Science, NYU Shanghai, Shanghai, China.
8
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA. Electronic address: osten@cshl.edu.

Abstract

The stereotyped features of neuronal circuits are those most likely to explain the remarkable capacity of the brain to process information and govern behaviors, yet it has not been possible to comprehensively quantify neuronal distributions across animals or genders due to the size and complexity of the mammalian brain. Here we apply our quantitative brain-wide (qBrain) mapping platform to document the stereotyped distributions of mainly inhibitory cell types. We discover an unexpected cortical organizing principle: sensory-motor areas are dominated by output-modulating parvalbumin-positive interneurons, whereas association, including frontal, areas are dominated by input-modulating somatostatin-positive interneurons. Furthermore, we identify local cell type distributions with more cells in the female brain in 10 out of 11 sexually dimorphic subcortical areas, in contrast to the overall larger brains in males. The qBrain resource can be further mined to link stereotyped aspects of neuronal distributions to known and unknown functions of diverse brain regions.

KEYWORDS:

Cell type; brain; cortex; inhibition; sexual dimorphism

PMID:
28985566
PMCID:
PMC5870827
DOI:
10.1016/j.cell.2017.09.020
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center