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Nat Med. 2017 Oct 6;23(10):1124-1134. doi: 10.1038/nm.4409.

Cancer stem cells revisited.

Author information

1
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
2
Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
3
CiberONC, Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain.
4
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, University Medical Center Utrecht and Princess Maxima Center, Utrecht, the Netherlands.

Abstract

The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated stem cells. It has gradually become clear that many tumors harbor CSCs in dedicated niches, and yet their identification and eradication has not been as obvious as was initially hoped. Recently developed lineage-tracing and cell-ablation strategies have provided insights into CSC plasticity, quiescence, renewal, and therapeutic response. Here we discuss new developments in the CSC field in relationship to changing insights into how normal stem cells maintain healthy tissues. Expectations in the field have become more realistic, and now, the first successes of therapies based on the CSC concept are emerging.

PMID:
28985214
DOI:
10.1038/nm.4409
[Indexed for MEDLINE]

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