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J Complement Integr Med. 2017 Oct 6;15(2). pii: /j/jcim.2018.15.issue-2/jcim-2016-0141/jcim-2016-0141.xml. doi: 10.1515/jcim-2016-0141.

The effect of celery (Apium graveolens L.) on fertility: A systematic review.

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Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Department of Biology, School of Science, Shahid Chamran University, Ahvaz, Iran.
Sophmore/Health and Medical Studies, Henry Ford Early College at Henry Ford College, Dearborn, MI, USA.
Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.
Student Research Committee, Dezful University of Medical Sciences, Dezful, Iran.
Department of Immunology, Faculty of Medicine, Ahvaz Joundishapour University of Medical Sciences, Ahvaz, Iran.


Background Fertility and infertility problems are among the complex issues in medicine. The use of herbal products in the treatment of fertility has been considered as an alternative to synthetic drugs. Celery containing known compounds can have an impact on the fertility rate. The aim of this study was to do a systematic review on conducted studies in conjunction with the celery and reproduction. Methods Required papers were searched from databases like Science direct, PubMed, Scopus, and Springer. Keywords used in this study were "Apium graveolens L.", "fertility", "reproductive system", "sperm", "testis", "delivery", "sexual hormone", "LH", "FSH", "testosterone", "semen", "male", and "female". Out of 238 collected articles (published in the period 1995 to 2015), 222 were excluded due to non-relevance and lack of access to the original article. Results The notable points were the different results seen by different researchers during different treatment periods or at different doses. Of the 16 studies reviewed in this study, 13 studies have mentioned the positive effect of celery on fertility, while three studies reported the inhibitory effects of this plant. Conclusions Celery can have protective effects against substances such as sodium valproate, propylene glycol, and diethyl phthalate causing damages to the testicular structure and spermatogenesis. In this regard, the doses used and the treatment time while using the plant must be accurately investigated. Since there are compounds such as apigenin, the celery can induce inhibitory effects on fertility in case of chronic use or high concentration.


Apium graveolens L.; fertility; reproductive

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