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CNS Oncol. 2017 Oct;6(4):269-274. doi: 10.2217/cns-2017-0010. Epub 2017 Oct 6.

Neurological improvement of perineural and leptomeningeal spread of squamous cell carcinoma treated with intrathecal chemotherapy and systemic EGFR inhibition.

Author information

1
Department of General Practice & Elderly Care Medicine, Amsterdam Public Health Research Institute, VU University Medical Centre, 1081 BT Amsterdam, The Netherlands.
2
Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute & Pacific Neuroscience Institute at Providence Saint John's Health Center, Santa Monica, CA 90404, USA.
3
Department of Neurosciences, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

Abstract

Squamous cell carcinoma (SCC) is a common cancer of the skin. Risk factors include fair skin, excessive sun and ultraviolet light exposure, and history of xeroderma pigmentosa. Perineural invasion (PNI), an uncommon manifestation of SCC, involves microscopic tumor cells invading various layers of the nerve sheath. It is associated with a poorer prognosis. Standard treatment for PNI includes radiation therapy. Here, we describe a case an older gentleman with a history of SCC with PNI successfully treated with erlotinib and intrathecal chemotherapy.

KEYWORDS:

EGFR inhibitors; cutaneous squamous cell carcinoma; leptomeningeal metastasis; perineural invasion

PMID:
28984139
PMCID:
PMC6004881
DOI:
10.2217/cns-2017-0010
[Indexed for MEDLINE]
Free PMC Article

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