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Endocrinology. 1988 Jul;123(1):227-9.

Localization of pancreastatin immunoreactivity in porcine endocrine cells.

Author information

1
Institute of Histology and Embryology, University of Geneva Medical School, Switzerland.

Abstract

Pancreastatin is a peptide isolated from the porcine pancreas and shown to inhibit insulin release. We have studied the immunocytochemical distribution of pancreastatin in three porcine endocrine tissues: pancreas, gut, and adenohypophysis. Pancreastatin-specific immunoreactivity was found in all three locations and distributed to numerous cells. In the pancreas, we performed the alternate labeling of consecutive thick (immunofluorescence) or thin (protein A-gold) sections and we observed that pancreastatin colocalizes to secretory granules of insulin and somatostatin-containing cells. The relationship of pancreastatin to chromogranin A is discussed.

PMID:
2898359
DOI:
10.1210/endo-123-1-227
[Indexed for MEDLINE]

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