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Anticancer Res. 2017 Oct;37(10):5577-5583.

Clinical Impact of Re-irradiation with Carbon-ion Radiotherapy for Lymph Node Recurrence of Gynecological Cancers.

Author information

1
Hospital, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
2
Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Japan.
3
Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka, Japan.
4
Hospital, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan wakkun100@yahoo.co.jp.
5
Department of Radiology, Jichi Medical University, Shimotsuke, Japan.
6
Cyber Center, Kanto Neurosurgical Hospital, Kumagaya, Japan.
7
Department of Radiation Oncology, Maebashi Red Cross Hospital, Maebashi, Japan.
8
Department of Radiation Oncology, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan.

Abstract

BACKGROUND/AIM:

To evaluate the safety and efficacy of re-irradiation with carbon-ion radiotherapy (C-ion RT) for lymph node recurrence of gynecological cancers after definitive radiotherapy.

PATIENTS AND METHODS:

Data regarding patients with unresectable and isolated recurrent lymph node from gynecological cancer after definitive radiotherapy were analyzed. Total dose of C-ion RT was 48-57.6 Gy (RBE) in 12 or 16 fractions.

RESULTS:

Sixteen patients received re-irradiation by C-ion RT were analyzed. Median follow-up was 37 months. Median tumor size was 27 mm. None developed Grade 1 or higher acute toxicities and Grade 3 or higher late toxicities. The 3-year overall survival, local control and disease-free survival rates after C-ion RT were 74%, 94% and 55%, respectively.

CONCLUSION:

Re-irradiation with C-ion RT for lymph node recurrence of gynecological cancers after definitive radiotherapy can be safe and effective. This result suggested that C-ion RT could be a curative treatment option for conventionally difficult-to-cure patients.

KEYWORDS:

Carbon-ion radiotherapy; gynecological cancer; lymph node recurrence; re-irradiation

PMID:
28982873
DOI:
10.21873/anticanres.11991
[Indexed for MEDLINE]

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